|
Symbol Name ID |
Cd40
CD40 antigen MGI:88336 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Increased circulating IgA level |
Decreased circulating IgE |
Decreased circulating IgG level |
Increased circulating IgG level |
Increased circulating IgM level |
Decreased circulating antibody level |
Paraproteinemia |
Impaired Ig class switch recombination |
Impaired memory B cell generation |
Neutropenia |
Decreased proportion of CD4-positive helper T cells |
Leukopenia |
Pericarditis |
Abnormal lymph node morphology |
Absence of lymph node germinal center |
Lymphadenopathy |
Abnormality of the spleen |
Splenomegaly |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Anti-citrullinated protein antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Rheumatoid factor positive |
Systemic lupus erythematosus |
Immunodeficiency |
Asthma |
Recurrent bacterial infections |
| Disease(s) Associated with CD40 | |||||||||||||||||||||||||||||||||||||||||
| asthma | |||||||||||||||||||||||||||||||||||||||||
| Burkitt lymphoma | |||||||||||||||||||||||||||||||||||||||||
| immunodeficiency with hyper IgM type 3 | |||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | |||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
decreased neutrophil cell number |
absent germinal center B cells |
decreased B cell number |
absent spleen germinal center |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
increased IgG3 level |
decreased IgG level |
decreased IgM level |
increased IgM level |
decreased immunoglobulin level |
abnormal lymph node germinal center morphology |
abnormal dendritic cell physiology |
decreased susceptibility to type II hypersensitivity reaction |
abnormal humoral immune response |
impaired humoral immune response |
increased susceptibility to bacterial infection |
abnormal response to transplant |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Cd40m1Btlr/Cd40m1Btlr | |||||||||||||||||||||||||||
| Cd40m2Btlr/Cd40m2Btlr | |||||||||||||||||||||||||||
| Cd40tm1Arah/Cd40tm1Arah | |||||||||||||||||||||||||||
| Cd40tm1Geha/Cd40tm1Geha | |||||||||||||||||||||||||||
| Cd40tm1Kik/Cd40tm1Kik | * | ||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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